ZFIN Image: Caceres et al., 2019, Fig. 4

Image

Figure Caption

Fig. 4 Loss of fzd4 results in increased retinal vessel density and endothelial cell proliferation. A‐B, Thin cellular projections (arrows) emanating from the red foci of the endothelial cell bodies (arrowheads) to form a kinked and branching pattern in the vasculature are detected in both, A, control and B, fzd4 mutant retinas. Green fluorescent protein (GFP) (red) marks retinal vasculature. Scale = 200 μm. C‐D, Quantification of cellular fusion and proliferation shows a progressive increase over time in vessel density of fzd4 mutants compared to controls and itself at earlier time points (compare fzd4 week 9 to fzd4 week 12). Furthermore, this increase in vessels density results from increase in endothelial proliferation as shown in D

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.