MS/MS analysis of Larp6 mutant zebrafish chorions reveals altered composition. (A-C) Volcano plots showing the extent and significance of altered proteins in samples of 30 chorions from MZlarp6a;MZlarp6b (A), MZlarp6a (B) and MZlarp6b (C) incrosses. (D) Venn diagram showing overlap of significantly downregulated chorion proteins in each mutant. (E) Hierarchical clustering of the protein intensity values for significantly altered proteins across the triplicate wild-type and double mutant samples. Uniprot ID is on the left. Gene IDs (where available) are on the right: green, lectin proteins; blue, zona pellucida proteins.
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