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Sarmah et al., 2020 - Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects

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Figure 2

Ethanol induced gene expression changes during zygotic genome activation. (A) Venn diagram shows overlapping of ethanol dysregulated genes identified in the Affymetrix GeneChip microarray analysis of control and ethanol treated embryos at 4.5 hpf with potential Sox2 targets and the genes differentially expressed in quadruple knockdown of SoxB1 factors, which includes Sox2 (Soxb1 QKD targets). (B) Twenty five of the ethanol-dysregulated transcription factors showing the enrichment of their targets in our ethanol-dysregulated gene set. (C) Transcription factor-target gene network visualizing using cytoscape shows interactions among the transcription factors (gold circles) and their target gene (blue circles) in our dataset. Ethanol dysregulated targets of Sox2 are co-shared by other dysregulated transcription factors.

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