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Figure 3

ID: ZDB-IMAGE-200310-44
Publication: Leinonen et al., 2019 - LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels
All Figures: Figures for Leinonen et al., 2019

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Figure 3

Summary of the RNA-Seq experiment examining the global RNA expression in the lin28b mutant fish at 1d and 7d. (A) Sampling and study design. After dissecting the anterior part from embryos/larvae, we pooled 6–10 samples together. The resulting 4–6 biological replicates per group were subjected to RNA sequencing. (B) Plots of mean logFC differences between the lin28b −/− and the +/+ fish at 1dpf (upper panel), and at 7dpf (lower panel). The genes showing significantly different expression in the global analysis (p < 0.00005, FDR < 0.1) are highlighted in red. (C,D) Results from the gene ontology analysis by GSEA, showing the GO categories differentiating between the lin28b −/− and the +/+ groups. E) Enriched GO terms in the lin28b −/− fish from the GOrilla analysis. Upper panels shows the results for the 1dpf fish and the lower panel for the 7dpf zebrafish.

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