ZFIN Image: Wang et al., 2020, Figure 4

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Figure 4

CYM-5478 attenuates apoptosis and oxidative stress in neural cells. (A) C6 glioma cells were treated with cisplatin (20 μM) for 24 h in the presence of increasing concentrations of CYM-5478, then evaluated for caspase 3/7 activity. (n = 6.) (B) cDNA prepared from CLU-188 mouse hypothalamic cells and 4T1 mouse mammary carcinoma cells was amplified with gene-specific primers. S1P₂ is the most abundant S1P receptor present in both cell lines. (C) CLU-188 cells and 4T1 cells were treated with cisplatin (20 μM) overnight in the presence or absence of CYM-5478, then evaluated for ROS using the CellROX assay. (n = 5, * p < 0.05, ** p < 0.01).

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