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Figure 5
CYM-5478 promotes anti-apoptotic pathways in neural but not breast cancer cells. Cisplatin (20 µM) and CYM5478 (20 µM) either alone or in combination were treated for 24 h, after which western blot analysis was performed. CYM-5478 reverses cisplatin-induced suppression of anti-apoptotic phospho-STAT3 and Bcl-xL while inhibiting expression of pro-apoptotic Bax in CLU-188 mouse neural cells. CYM5478 had no effect on cisplatin-induced suppression of phospho-STAT3 or Bcl-xL, and did not suppress Bax in 4T1 mouse breast cancer cells.
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