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Fig 4

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Publication: Concilio et al., 2020 - Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)
All Figures: Figures for Concilio et al., 2020

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Fig 4 Characterization of radioisotope substrate uptake in HeLa cells lentivirally transduced with HA-human NIS, HA-minke whale NIS, or HA-zebrafish NIS.

Raw uptake value of (A-B) ¹²⁵I^-, (C) ^99mTcO₄^-, or (D) B¹⁸F₄^- in the absence or presence of 50 μM perchlorate (ClO₄) in transfected or transduced cells. (E-H) Uptake of each radioisotope normalized to hNIS uptake via cell surface protein expression. (I-L) The percentage of maximum ¹²⁵I^- uptake activity (uptake at 0 μM ClO₄) maintained in the presence of 50 μM perchlorate (ClO₄). Values are averages of triplicate assays with standard deviation. n.s. indicates not significant; * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001; **** indicates p < 0.0001; Untrans. = untransfected or untransduced.

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