ZFIN Image: Xu et al., 2020, Figure 4

Image

Figure Caption

Figure 4

Estrogen accelerates scar reduction and promotes recovery of cardiac function. (A) Picrosirus red staining of the heart from female zebrafish treated with DMSO, E2 (1 nM) and tamoxifen (1 μM); and male zebrafish treated with DMSO and E2 (1 nM) at 30 dpc. Scale bar: 200 μm. (B) Quantification of scar volume from samples in panel A (marked by dash lines, mean ± s.d., n = 5~6). One-way ANOVA with LSD post hoc test, *P < 0.05, **P < 0.01, and ***P < 0.001. (C) Fractional shortening (FS) measured by echocardiography of male zebrafish before (basal) and at different time points during recovery in DMSO or E2 (1 nM) after CI. Two-way ANOVA with LSD post hoc test, *P < 0.05, n = 5~6.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Endocrinol.