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Figure 4
Fisetin regulated a panel of genes related to cardioprotection, proliferation and maturation. Gene expression was assessed by qRT-PCR in cells cultured under normoxia, subjected to HS/R and treated with DMSO as vehicle control (HS/R) or subjected to HS/R and treated with 15 μM fisetin (HS/R + F) during 24 h. Results are expressed as the mean of four independent experiments. Statistical significance was determined using a one-way ANOVA corrected for multiple testing with a Tukey-Kramer as post-test (corrected p-value < 0.05). Statistically significant results are indicated in bold with a star. Fold change < 1: genes down-regulated compared to normoxia (yellow). Fold change > 1: genes up-regulated compared to normoxia (blue).