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Figure 10
A proposed mechanism of 4-HPPP-induced antiproliferation and apoptosis in NSCLC cells through modulating the signaling of endogenous antioxidant systems, such as SOD2 and PRX1, causing DNA damage and high-grade aneuploidy. Eventually, the accumulation of DNA damage and hyperaneuploidization induce apoptosis in NSCLC cells.
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