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Figure 9.

ID: ZDB-IMAGE-200210-47
Publication: Nagashima et al., 2019 - Midkine-a is required for cell cycle progression of Müller glia glia during neuronal regeneration in the vertebrate retina
All Figures: Figures for Nagashima et al., 2019

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Figure 9.

Activation of the ALK receptor is required for Müller glial to proliferate. A, Double immunostaining for PCNA (magenta) and pAlk (green). PCNA⁺ cells express pAlk in WT retina at 2 dpl, whereas pAlk immunostaining was not detected in mdka^mi5001 retina. Scale bar, 30 μm. B, Pharmacological inhibition of Alk using TAE684 suppresses proliferation in the WT retinas after a lesion. C, Counts of PCNA⁺ proliferative cells in DMSO- or TAE684-treated WT retinas at 3 dpl. n = 7. *p = 0.0011 (nonparametric Mann-Whitney-Wilcoxon).

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