IMAGE

Fig. 5

ID

ZDB-IMAGE-200207-5

Genes

EGFP
mCherry

Publication

Tian et al., 2020 - Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration

All Figures

Figures for Tian et al., 2020

Image

Figure Caption

Fig. 5 Schwann cells develop normally in Sarm1-deficient zebrafish.

a Confocal images of a double-transgenic 5dpf larva showing Schwann cells marked by expression of GFP (green) under the control of the Tg[gSAGFF202A] Gal4 driver, and lateralis afferent neurons marked by expression of mCherry under the control of the SILL enhancer (red). Wild type (top), Sarm1 mutants (bottom). Scale bar 20 μm. b Images show the indicated time points after axon transection (hours post-injury = hpi) from a videomicroscopic recording of Schwann cells (green) and their interaction with axons (red) in wild type and Sarm1−/−. White arrowheads indicate Schwann cells engulfing axonal debris in the wild type. A white arrow indicates degradation-resistant axon segment in Sarm1−/−. Please note that the proximal axon stump in Sarm1−/− is not visible in these images because it is outside the focal plane.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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