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Fig 5

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Publication: Hin et al., 2020 - Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
All Figures: Figures for Hin et al., 2020

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Figure Caption

Fig 5 Protein abundance changes in the brains of heterozygous mutant (<italic>psen1</italic><sup><italic>K97fs/+</italic></sup>) zebrafish compared to wild type (<italic>psen1</italic><sup>+/+</sup>) siblings at 6 months (young) and 24 months (aged).

Protein abundance was quantified at the peptide-level with LC-MS/MS (liquid chromatography tandem mass spectrometry) and differential abundance was assessed using moderated t-tests (limma). Differentially abundant proteins are defined as those with FDR-adjusted p-value < 0.05. Protein names were used to retrieve equivalent gene symbols for display purposes on these heatmaps. (A) Differentially abundant proteins between young heterozygous mutant and wild type zebrafish brains. (B) Differentially abundant proteins between aged heterozygous mutant and wild type zebrafish brains. The proteins have been clustered according to their abundance changes across the four comparisons.

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