IMAGE

Fig 3

ID: ZDB-IMAGE-200206-4
Publication: Hin et al., 2020 - Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
All Figures: Figures for Hin et al., 2020

Image

Figure Caption

Fig 3 Differential gene expression between heterozygous mutant (<italic>psen1</italic><sup><italic>K97fs/+</italic></sup>) and wild type (<italic>psen1</italic><sup>+/+</sup>) zebrafish brains at 6 months (young) and 24 months (aged).

Only genes with absolute log₂ fold change > 0.5 are shown. Genes were considered differentially expressed if their moderated t-test FDR-adjusted p-value was below 0.05. (A) Differentially expressed genes at 6 months. (B) Differentially expressed genes at 24 months. The differentially expressed genes are grouped into clusters based on gene expression changes across the four comparisons. Overall, note the similar expression changes in ‘young heterozygous mutant vs. young wild type’ and ‘aged wild-type vs. young wild-type’ and the contrast of these to comparisons involving aged heterozygous mutants. This illustrates the accelerated brain aging in young heterozygous mutant brains and the "inverted" gene expression pattern of aged heterozygous mutant brains.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One