ZFIN Image: Qiu et al., 2019, Fig. 4

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Figure Caption

Fig. 4 Validation of Mirror Craniofacial Effects in Rat and Mouse Models of 16p11.2 Deletion and Duplication

All pairwise distances were analyzed for nineteen landmarks on the dorsal skull and three on the mandible as shown here and in Table S4. Distances are colored according to craniofacial region using the same scheme as in Figure 1. Distances that span multiple craniofacial processes are denoted as “other.” ML, mandibular length; MW, mandibular width.

(A) In the rat models, 52 individual features differed significantly by genotype. Regression coefficients for the duplication deletion show significant mirror effects.

(B) Informative features were identified by LASSO selection, and features that correspond to a specific facial process in rat are shown.

(C) In the mouse models, 12 craniofacial measures that discriminated mutant and control groups were selected by LASSO. Regression coefficients of these features show mirror effects of deletion and duplication similar to those in human and rat.

(D) Features that correspond to specific facial processes in mouse.

Acknowledgments

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