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Figure 4

ID: ZDB-IMAGE-200101-31
Publication: Murat El Houdigui et al., 2019 - A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafish
All Figures: Figures for Murat El Houdigui et al., 2019

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Figure 4

(a) Number of transcription factors (TF) with significant deregulation (|fold change| ≥ 1.5 and adjusted p-value < 0.01) over developmental time at three different dose rates. (b) Hierarchical clustering of 462 TF misregulated in at least one comparative analysis. Blue indicate downregulation, white no change and red upregulation, as compared to control conditions. Clusters of co-regulated genes are indicated at the right from 1 to 6. (c) GO enrichment of TF classified in 6 different clusters. Cluster number are indicated below, the total number of deregulated TF in each GO term in brackets. (d) Expression patterns (as normalised count) of key master regulators during development using loess smoothed conditional means. Cluster numbers are indicated at the top. *|fold change| ≥ 1.5 and adjusted p-value < 0.01.

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