ZFIN Image: Zhang et al., 2019, Figure 5

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Figure Caption

Figure 5

Altered ceramide distribution in Farber disease zebrafish. (a) Quantification for selected ceramides from 3.75-month DKO and SKO zebrafish brains (see Table S4 for quantification of additional ceramide species). (b) Total ceramide content in 3.75-month DKO and SKO zebrafish brains. (c) Total ceramide content by even and odd carbon number. Even: even number of carbons in both acyl chain and LCB; odd: odd number of carbons in acyl chain and/or LCB. (d) Total ceramide content by degrees of unsaturation. Monounsaturated ceramide: one double bond in LCB; diunsaturated ceramide: one additional double bond relative to monounsaturated species. (e) DKO/SKO fold change by LCB length. (f) DKO/SKO fold change by acyl chain length. Student t-test, SEM, n = 4 per group. Representative data from two independent experiments are shown ***p < 0.001.

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Phenotype details

Acknowledgments

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