ZFIN Image: Misselbeck et al., 2019, Fig. 1

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Fig. 1

Schematic illustration of the computational framework. Step 1 MetSyn-related genes are identified by combining GWAS results and literature findings followed by a filtering step based on gene-set enrichment analysis. Step 2 Tissue-specific networks are constructed by integrating transcriptional regulatory networks from²³ and PPI networks from HIPPIE db²⁵. Step 3 Drug information is retrieved from DrugBank²⁹ and LINCS database¹¹. Step 4a and b Tissue-specific MetSyn and drug modules are established using network analysis. Step 5 To measure drug effects, a proximity score between drug and MetSyn modules is computed on the basis of network distance and semantic similarity

Acknowledgments

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