Figure 4

Figure 4

Potential regulatory interactions between regeneration-associated transcription factors and putative promoters and enhancers. (A) Stacked bar graph of number of peaks enriched with transcription factor (TF) motif in the proximal (gray) and distal (black) sequences for each TF in the cluster axon growth towards midline (cluster 1 in Fig. 1). (B) Heat map of shared TF motif enrichment in cluster1 accessible peaks. X-axis = number of shared TF motifs enriched in peaks, Y-axis = TF. Heatmap colors based on % of total peaks enriched for given TF. (C) Pair-wise co-occurrence of TF motifs found in the proximal and distal accessible regions surrounding the differentially expressed transcripts of cluster 1. Node color corresponds to TF family based on DNA-binding domain (DBD). bHLH, basic helix-loop-helix; bZIP, basic leucine zipper; C2H2 ZF, two cys, two his zinc finger; Ets, E26 transformation-specific; Rel, member of NF-kB family; STAT, signal transducer and activator of transcription. Node size corresponds to percentage of peaks enriched for given TF. Edge thickness corresponds to % shared enriched peaks.