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Fig. 5

ID: ZDB-IMAGE-191230-762
Publication: Hall et al., 2019 - Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A
All Figures: Figures for Hall et al., 2019

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Fig. 5

lama2^−/− mutant larvae possess defects in muscle stem and progenitor cell formation that are rescued by Laminin protein injection. a–c The transgenic line TgBAC(pax3a:GFP) marks muscle stem and progenitor cells in zebrafish larvae. lama2^−/− mutants (b) possess reduced numbers of pax3a-GFP-positive cells compared to WT (a), quantitated in c (Results expressed as mean ± SD. For each group, n ≥ 11. Statistics: t-test, two-tailed; ****p < 0.0001). d, e Intramuscular injection of fluorescently labelled Laminin protein (red) into lama2^−/− mutants (e) rescues pax3a-GFP-positive cell numbers, and increases them significantly over WT levels (d), quantitated in f (Results expressed as mean ± SD. For each group, n ≥ 7. Statistics: one-way ANOVA, Tukey’s test; *p < 0.05, **p < 0.01). Scale bars, 20 μm

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