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Fig. 5

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Publication: Giallongo et al., 2019 - TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma
All Figures: Figures for Giallongo et al., 2019

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Fig. 5 Inhibition of TLR4 signaling in MM-MSC decreased PC engraftment in vivo.

MM-MSC (from five patients) were pre-treated with TAK-242 before co-injection with PC. Three animals were engrafted for every group. a Evaluation of tumor xenograft was performed by tomography after 3 days. Tumor growth within 3 days of engraftment in animals injected with PC + MM-MSC: p < 0.05; tumor reduction within 3 days in animals injected with PC + MM-MSC pretreated with TAK-242 5 μM: p < 0.01. Difference between the two groups: p < 0.001. b Analysis of changes in the Th1/Th2 balance in zebrafish. *p < 0.05; **p < 0.01

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