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Figure 1—figure supplement 3.

ID: ZDB-IMAGE-191230-1662
Publication: Fillatre et al., 2019 - TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish
All Figures: Figures for Fillatre et al., 2019

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Figure Caption

Figure 1—figure supplement 3. Phenotype of <italic>vgll4l</italic>, <italic>vgll4b</italic>, <italic>yap</italic>,<italic>taz</italic> and <italic>tead3a</italic> homozygous mutant embryos.

(A–F) Side view of live WT embryo (A) and of embryos homozygous (-/-) mutant for vgll4l (B), vgll4b (C), yap (D), taz (E) and tead3a (F) at 2 days of development showing that the global morphology of the embryo is not affected by loss of function of these TFs/TcoFs. (G–L) Cardiac jogging at 25 hr post fertilization (hpf) in (G) WT (L jog: left jog) and in homozygous mutants visualized by in situ hybridization with myosin light chain 7 (myl7) probed at 25 hpf for vgll4l (H), vgll4b (I), yap (J), taz (K) and tead3a (L) mutants. Embryos with abnormal laterality (R jog - right jog or no jog) are presented. Embryos are in front view except in (L), R jog) presented in dorsal view.

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