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Fig 12

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Publication: Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway
All Figures: Figures for Sucharov et al., 2019

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Fig 12 Liability-threshold model and tuned circuitry model for <italic>mef2ca</italic> heritable variable penetrance.

(A) The liability-threshold model illustrates the inheritance of ectopic bone penetrance in mef2ca mutants following selective breeding. The difference between the mean of the population and the threshold is defined as x. x_F0-op = 0.468, x_high-op = -1.080 and x_low-op = 1.918. (B) The multiple threshold model illustrates how the same modifiers can shape liability and penetrance of different mef2ca mutant phenotypes to different extents. x_{high-jaw joint} = -4, x_{low-jaw joint} = -.806 x_high-op = -1.08 x_low-op = 1.476. (C) Model for how tuning down of Jag/N-driven transcription of her6 can result in mef2ca low penetrance. This genetic circuitry downstream of mef2ca is consistent with mutant, genetic epistasis, and gene expression analyses in this study.

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