Fig. 5

Fig. 5

Conserved and novel homologues of bilaterian genes involved in axis patterning and regulated by the Wnt/β-catenin signalling pathway in Hydra. a Stacked bar plot depicts shared homologues of planaria and Xenopus that are differentially regulated by the Wnt/β-catenin signalling pathway in Hydra. b Predicted gene regulatory network of dorsoventral patterning genes based on differentially expressed gene under wnt activation condition. Genes highlighted in red colour are upregulated and genes highlighted in blue are downregulated; dotted line, β-catenin-dependent or -independent regulation. c Transcription factor targets of Wnt/β-catenin signalling identified in Hydra. TFs highlighted in red are also observed as part of the Spemann’s organizer signature⁴⁶.