ZFIN Image: Aleksandar et al., 2019, Fig. 4

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Figure Caption

Fig. 4

Myeloprotective effect of Allium extracts against Dox toxicity in Tg(mpx:EGFP) zebrafish embryos. Neutrophils occurrence (A) and the fluorescence intensity (B) upon different treatments are shown. While Dox caused severe neutrophils depletion (neutropenia) and large pericardial edema (arrow) at 10 μg/ml, extracts applied at a dose of 5 μg/ml had no toxic effect on neutrophils, while exerted both myeloprotective and cardioprotective effect in the combination treatments. Strong fluorescence in the yolk sac region in Dox-treated embryos originates from Dox accumulation. Statistically significant differences in neutrophil occurrence between the control (0.1% DMSO-treated) group and the groups upon single treatments (*P < 0.5, **P < 0.01; ***P < 0.001), and between the Dox-treated group and the groups upon the combination treatments (#P < 0.5, ##P < 0.01; ###P < 0.001) are denoted.

Acknowledgments

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