ZFIN Image: Aleksandar et al., 2019, Fig. 5

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Figure Caption

Fig. 5

In vivo anti-angiogenic effect of Allium extracts applied alone (A and B) and in combination with Dox (C). Effects of the treatments on intersegmental vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs), as well as on subintestinal vessels (SIVs) development in Tg(fli1:EGFP) zebrafish embryos were assessed at 48 hpf and 72 hpf, respectively. Normally developed ISVs, DLAVs and SIVs are designated in the control (0.1% DMSO-treated) embryo, while disrupted DLAVs (asterisk), thinner or reduced ISVs (arrow) and reduced SIVs (arrowhead) are designated upon applied treatments. Statistically significant differences in ISVs length between the control group and the groups upon treatments (***P < 0.001) as well as between the Dox-treated group and the groups upon the combination treatments (###P < 0.001) are denoted.

Acknowledgments

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