Fig. 8
spr mutants show signs of chromosome instability. DAPIstaining and anti-alphaTubulin staining in the wild-type embryo (A-A″), the sprtu21 mutant (B-E″), sprtu21/ro1 transheterozygote (F-H″), and the sprro1 mutant (I-J″) at 24 h. Symbols are: red arrows, chromosome separation defects; red arrowheads, pyknotic nuclei suggestive of cell death; white arrowheads, polar microtubules; open white arrowheads, astral microtubules; open white arrows, apoptotic microtubules; white arrows, abnormal spindle microtubule organization; dashed line, expected spindle orientation; solid line, observed spindle orientation. Scale bar is 10 μm.
Reprinted from Developmental Biology, 451(2), Petrachkova, T., Wortinger, L.A., Bard, A.J., Singh, J., Warga, R.M., Kane, D.A., Lack of Cyclin B1 in zebrafish causes lengthening of G2 and M phases, 167-179, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.