IMAGE

Fig. 3

ID
ZDB-IMAGE-190913-66
Genes
Source
Figures for Leerberg et al., 2019
Image
Figure Caption

Fig. 3

fgfr1a and fgfr1b function redundantly to regulate posterior mesoderm development. (A–D) Lateral view of 30 hpf wild-type (WT; A), and Zfgfr1a;Zfgfr1b (B), Zfgfr1a;MZfgfr1b (C), and MZfgfr1a;Zfgfr1b (D) mutant embryos. Arrowheads denote the notochord; arrows mark pooled blood cells in (B and C). Anterior is to the left, dorsal is up. (E–G) Mesodermal derivative marker analysis of Zfgfr1a;MZfgfr1b and MZfgfr1a;Zfgfr1b double mutant embryos at the 10-somite stage. The notochord (labeled with ta, brown; filled arrowhead) extends down the length of the trunk and tail in wild-type (E) and Zfgfr1a;MZfgfr1b double mutant embryos (F), but is truncated in MZfgfr1a;Zfgfr1b double mutant embryos (G). Defined somites (labeled with myod, purple; open arrowhead) are present in wild-type embryos (E) and Zfgfr1a;MZfgfr1b embryos (F); however, the latter have distinctly fewer somites (5 compared to 10). Although MZfgfr1a;Zfgfr1b mutants retain some myod-positive cells, there are no definitive somites (G). Pronephric precursors (labeled with pax2a, purple; brackets) are restricted to a defined band around the trunk and tail of wild-type embryos (E), a region that is expanded in both Zfgfr1a;MZfgfr1b (F) and MZfgfr1a;Zfgfr1b double mutant embryos (G). Bars: in (D), 200 μm for (A–D); in (G), 50 μm for (E–G).

Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genetics