ZFIN Image: Paone et al., 2018, Figure 1

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Figure 1

GWAS and zebrafish: a powerful combination for cardiovascular research. The benefits of the zebrafish as an experimental system can enormously help to validate the functional relevance of candidate genes identified by GWA studies. In addition, the system enables the in vivo analysis of underlying pathomechanisms and is highly suitable for high throughput screening applications. In summary, the combination of GWAS and the zebrafish experimental system has the potential to lead to improved and specific therapeutic approaches.

Acknowledgments

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