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Fig. 2
Endocytosis mechanism essential for Wnt/β-catenin signaling. In the Wnt off state, β-catenin is continuously degraded. Wnt presentation to the receiving cell leads to signalosome formation (1). The signalosome is taken up into the cell (2). Disassembly of the Clathrin lattice (blue dashed line) leads to separation of the endocytic vesicles carrying the ligand and the β-catenin/destruction complex, which becomes deactivated (3). Next, β-catenin accumulates and starts to regulate the transcription program in the nucleus (4)
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