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Figure 3
Schematic representation of a proposed scenario of the insulin-like growth factor-binding protein (IGFBP) family evolution. A single ancestral IGFBP gene was duplicated in an early chordate. This duplication was followed by two successive rounds of chromosomal duplications or tetraploidization events in early vertebrates. Of the eight IGFBPs that resulted from this process, two were subsequently lost, leaving six types of IGFBPs that are seen in modern vertebrates.
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Full text @ Front Endocrinol (Lausanne)