ZFIN Image: Potts et al., 2017, Figure 1

Image

Figure Caption

Figure 1

Hematopoietic phenotype conserved in zebrafish model of AML-ETO driven AML. (A,B) Wright–Giemsa stained blood cells from (A) human acute myeloid leukemia (AML) patient bone marrow smear demonstrating accumulation of promyelocytes [modified and published with permission from Ref. (52)] and (B) zebrafish peripheral blood smear showing accumulation of myeloid blasts from AML-ETO overexpressing embryos at 40 hpf. (C) Rescue of hematopoietic phenotype with trichostatin A (TSA) treatment. Inducible Tg[hps:AML1-ETO] line utilized, such that heat-shocked Tg embryos treated with DMSO develop AML-like phenotype, which can be reversed with TSA treatment. scl marks hematopoietic stem and progenitor cells; gata1 marks erythroid lineage; mpo marks myeloid lineage. Panels (B,C) modified and published with permission from Yeh et al. (50).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Oncol