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Figure 6
(A) Human p53 network. (B) Mouse p53 network. (C) Zebrafish p53 network. Models were constructed by Ingenuity Pathway Analysis. Red: predicted targets validated by 3 assays; Orange: predicted targets validated by 2 assays; Yellow: predicted targets validated by 1 assay; Pink: predicted targets not validated by any assay, but validated by 3 assays in another species. (D) Incoherent feedforward loop (FFL) motifs characterize miR-125b regulation of p53 network genes that mediate apoptosis or cell cycle arrest.
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