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Figure 3
Structure of the Popeye domain. A homology-based structural model of human POPDC1 was generated. A space-filling model of cAMP was placed in the putative phosphate-binding cassette. The DSPE and FQVT motifs, depicted as yellow halos, surround the cAMP molecule and as mutagenesis studies suggest, seem to be directly involved in cAMP-binding.
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Full text @ J Cardiovasc Dev Dis