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Fig. 5-S1
Direct activation of calcineurin promoted the optimal maturity of neonatal mouse β-cells in isolated islets in vitro, as indicated by ex vivo islet calcium imaging.
(A) The experimental design for ex vivo islet calcium imaging used in (B–C). (B–C) Representative time courses of calcium transients under indicated glucose stimulations in islets that had been cultured in media with 5.6 mM glucose (B) and 11 mM glucose (C) for 3 days with or without CGA.
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