ZFIN Image: DuVal et al., 2018, Fig. 4

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Figure Caption

Fig. 4

Thrβ disruption with dnThrβ does not rescue the gdf6^s327/s327 blue cone phenotype. (A) Expression of dominant negative thrβ (dnthrβ) increases UV and blue cone abundances, but in gdf6a^s327^s327 mutants (labeled gdf6a^−/− or “−/−”) the low blue cone abundance is not changed and UV cones are not increased with dnthrβ expression. Gdf6a^s327^s327 mutants have reduced red cone abundance regardless of dnthrβ expression compared to nontransgenic wildtype siblings. Values with matching letters are not significantly different (Kruskal-Wallis test with Mann-Whitney pairwise comparisons, gray asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001 relative to WT sibling HS control). (B) Representative retinal images of wild-type sibling gdf6a^s327^s327 and gdf6a^s327^s327 with dnthrβ expression.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.