ZFIN Image: Chen et al., 2018, Fig. 2

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Figure Caption

Fig. 2 Mundoserone inhibits the trunk angiogenesis of zebrafish in a dose-dependent manner. Representative (A-E) bright field and (F-J) fluorescent images of zebrafish embryos at 24 h post-fertilization treated with 0.1% dimethyl sulfoxide (control), mundoserone (2.5, 5 or 10 �M) or 5 �M PTK787 (positive control) for 24 h (magnification, �40). (K-O) Magnification of images F-J (magnification, �112.5). Compared with the control, embryos exposed to mundoserone exhibited a lower number of incomplete ISVs and only occasional sprouts (asterisks) of the DA were observed. Quantification of (P) the number of complete ISVs and (Q) inhibition rate in mundoserone-treated embryos. Values are expressed as the mean � standard error of the mean (n=10). ***P<0.001. ns, not significant; DLAV, dorsal longitudinal anastomotic vessels; ISVs, intersegmental vessels; DA, dorsal aorta; PCV, posterior cardinal vein.

Acknowledgments

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