ZFIN Image: Lu et al., 2018, Fig. 5

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Fig. 5

Synergistic effect of kras^V12 expression and DSS on intestinal tumorigenesis. Four-mpf wild-type and kras+ fish were co-treated with 2 μM mifepristone and 0.0625% DSS for 3 weeks, and samples were collected for gross observations and histological analyses. There were four groups in the experiment: wild type, wild type/DSS, kras+,  and kras+/DSS. (A) Body length. (B) Body weight. (C) Survival curves. (D) Examples of normal, enteritis, hyperplasia, and tubular adenoma from H&E staining sections of intestine. Sources of the sections are indicated. (E) Summary of intestinal histological abnormalities observed in the four experimental groups. The data were generated as a result of a blinded histological analysis (wild type, n = 20; wild type/DSS, n = 20; kras+, n = 20; kras+ with DSS, n = 16). The differences among the variables were assessed using Student's t tests or one-way ANOVA. Statistical significance: *P < .05, **P < .01, and ***P < .001.

Acknowledgments

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