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Fig. S12
Pax6 expression in SB505124 and BIO-treated wild-type and rw341 mutant lenses
(A, B) Pax6 and PCNA expression of wild-type (A) and rw341 mutant (B) lenses. Panels in (B’) indicate higher magnification images of squares in (B), which cover lens epithelium. In DMSO-treated wild type, Pax6 is expressed in lens epithelium. SB505124/BIO-treatment did not affect Pax6 expression in wild-type lenses. In DMSO-treated rw341 mutants, Pax6 expression is low in anterior multilayered lens cells (B’, le). SB505124/BIO-treated rw341 mutants, lens epithelium is monolayered and express Pax6 (B’, arrows).
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