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Fig. 3
Melanoma model using TEAZ show evidence of rapid progression. (A) Pathology of tumor-bearing zebrafish (n=1) (along with control zebrafish, n=2) at 16?weeks postelectroporation, stained with H&E or anti-GFP immunohistochemistry, demonstrates a large primary tumor that is uniformly GFP+. (B-D) Histology reveals evidence of extensive invasion into the muscle (arrows) (B) along with micrometastatic sites within the kidney (C) or along blood vessels (arrows) (D). Images are visualized at 4× and 40×. Scale bars: 500??m (4×) and 50??m (40×). Dashed line boxes indicate the area enlarged at 40×.
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