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Fig. 5
bace2−/− Mutants Have Increased PI3K/mTOR Activity
(A–D) Immunostaining against phospho-S6 ribosomal protein (p-S6), a downstream readout of PI3K/mTOR activity, shows elevated p-S6 signal that overlaps with fluorophore-labeled melanophores at 48 hpf (B) and 72 hpf (C). A representative picture of 72 hpf is shown in (D) and overlapping signals are marked by arrowhead. The data are from three (A), five (B), and five (C) independent experiments, two-tailed t test, ∗∗∗∗p < 0.0001, ns = not significant. All bar graphs are presented as means ± SEM. Scale bar, 50 μm.
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Reprinted from Developmental Cell, 45(5), Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M., Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2, 580-594.e7, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell