ZFIN Image: Tiefenbach et al., 2018, Fig. S1

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Figure Caption

Fig. S1

Variability of GFP responses in PPAR? ligand trap embryos.

GFP responses in 2 dpf heterozygous PPAR? embryos are shown. Panels on the left show responses to endogenous ligand and cofactors in 3 different embryos. Signals are seen in the tail bud, as well as in the posterior spinal cord and skin, GFP (indicated by arrows). PPAR? embryos treated with idebenone (center panels), or rosiglitazone (right panels) show increased GFP expression in the tail bud and posterior spine as well as additional expression in the CNS and eye (indicated by arrows). Auto-fluorescence in the yolk is indicated by asterisks. Rosiglitazone treatment also elicited GFP expression in the heart (right panel upper image, indicated by arrow). Views are lateral with anterior to the left (avg n=10, replicated 20 times).

Acknowledgments

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