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Fig. 2
Bevacizumab impairs formation of zebrafish SIV in a dose-dependent manner.
Representative fluorescent images of control or embryos treated with bevacizumab at 3 dpf. In control embryos, SIVs developed as a smooth basket-like structure over the yolk at 3 dpf (A, yellow dashed lines). In contrast, embryos treated with bevacizumab resulted in specific defects in SIVs formation (B, C, white dashed lines). (D, E) Quantification of the area and number of SIV show significant decrease in bevacizumab-treated embryos. Error bars, SEM; *P<0.0001 (n=10; ANOVA).
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