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Fig. 1
Bevacizumab inhibits zebrafish retinal angiogenesis.
(A–D) Representative fluorescent images of control or embryos treated with bevacizumab at 4 dpf. In the control image panel, yellow lines indicate the vessel segments. Compared with control, higher magnification of the retinae revealed that collapsed vessels can be observed after bevacizumab treatment. (E) Quantification of the average number of blood vessel segments per eye shows a 11-fold decrease in bevacizumab-treated embryos (n=10) at 4 dpf. *Refers to P<0.0001 by an unpaired Student’s t-test.
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