ZFIN Image: Xing et al., 2018, Fig. 7

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Figure Caption

Fig. 7

The inducing-activity of Wnt8a is blocked in MZdvl2;MZdvl3a mutants.

In situ hybridization analysis of ectopic organizer gene expression at dome stage following Wnt8a overexpression in indicated embryos. Animal pole viewed embryos with dorsal region on the right. (A-F) goosecoid expression pattern in indicated embryos. (G-M) chordin expression pattern in indicated embryos. Notice that reduction of Dvl dosage progressively inhibits the inducing activity of Wnt8a, and MZdvl2;MZdvl3a embryos display a complete absence of ectopic goosecoid and chordin expression. All mutant embryos were derived from crosses between a female mdvl2^+(-)/-;dvl3a^-/- and a male dvl2^+/-;dvl3a^-/- fish, and were genotyped after in situ hybridization. Scale bar: 400 μm.

Acknowledgments

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