IMAGE

Fig. 7

ID

ZDB-IMAGE-180917-22

Genes

EGFP
TagBFP

Publication

Svahn et al., 2018 - Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

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Figures for Svahn et al., 2018

Image

Figure Caption

Fig. 7

Axonal redistribution of eGFP-TDP43^WT during UV-induced degeneration and microglia depletion. a Pre-irradiation, line is a projection of the axon vector used for signal analysis. Scale = 5 µm. bi–iv At each time point from left to right the three windows represents a single time point illustrating the cell body and the TDP-43 distribution (soma, eGFP-TDP43^WT in green), the axonal projection (axon, mTagBFP in magenta incl. neurite vector as yellow line), and the fluorescence intensity of eGFP in the segments along the neurite vector. c Line graph demonstrating the time course of the mean eGFP fluorescence intensity along the axon post-stress induction. Scale = 2 µm. Note: axonal redistribution was observed in 2 of the 10 neurons, which were targeted for UV injury and underwent degeneration

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol.