Fig. 6
Treatment with dmDf rescues the defects of stable kmt2d mutant. kmt2d+/? adults were in-crossed and the embryos were then collected at 1 dpf, 2 dpf and 5 dpf to assess dmDf efficacy. (a) dmDf ameliorates significantly the CE defect in kmt2d+/??×?kmt2d+/? progeny. (b) Treatment with dmDf increases significantly the brain cell proliferation of kmt2d+/??×?kmt2d+/? progeny. (c) administration of dmDf appears to ameliorate the differentiation delay in kmt2d+/??×?kmt2d+/? progeny. (d) dmDf rescues significantly the jaw defect in kmt2d+/??×?kmt2d+/? progeny. *p?<?0.05; **p?<?0.01; ***p?<?0.001. Error bars show SEM (standard error of the mean).