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Fig. S4

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Gauvrit et al., 2018 - HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
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Fig. S4

zebrafish hhex mutants exhibit increased hhex expression and the hhexs722 allele appears to encode a non-functional protein (a-b) Whole-mount in situ hybridization showing hhex expression in 32 hpf hhex+/+ and hhex-/- embryos. At 32 hpf, hhex-/- exhibit increased hhex expression in the vasculature (arrowheads point to ISVs). (c) hhex and hhexs722 mRNA injection at 50, 100 and 200 pg into one-cell stage wild-type embryos. Injection of wild-type hhex mRNA, but not hhexs722 mRNA, leads to developmental defects. Scale bars: 100 μm.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.