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Fig. 5
Unesterified cholesterol accumulation. (A) Control and mutant larvae were stained with filipin to visualize unesterified cholesterol. Filipin-positive puncta were initially observed in mutant larvae at 2 dpf in the area of the yolk sac extension and became more numerous with a wider distribution in older larvae. Scale bars: 200 µm. (B) Embryos were injected with TopFluor-cholesterol at the 1-cell stage and imaged at 7 dpf. Puncta of accumulated cholesterol were observed in the npc1m/m larvae. Scale bar: 1 mm.
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Full text @ Dis. Model. Mech.