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Fig. 4
Loss of tbx5a in adult zebrafish leads to severe regeneration defects.
Top, experimental outline. Bottom, sections of zebrafish hearts stained by Picro-Mallory stain. A-G. Hearts of zebrafish (n = 7) homozygous for the reverted tbx5a allele, and heterozygous for tnnt2:CreERT2, treated with ethanol (solvent for 4-HT). H, I. Hearts of zebrafish (n = 2) heterozygous for the reverted tbx5a allele, and heterozygous for tnnt2:CreERT2, treated with 4-HT. J-Q. Hearts of zebrafish (n = 8) homozygous for the reverted tbx5a allele, and heterozygous for tnnt2:CreERT2, treated with 4-HT.
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